![]() ![]() A wider variation in fentanyl plasma concentrations was found in this study than anticipated. Although no statistically significant difference was found, the plasma concentrations of non-smokers was 28% (95% CI ) higher than those of smokers normalizing for a dose of 25μg/min. We performed an explorative cohort study in patients with cancer using transdermal fentanyl patches (Durogesic ®), by taking a blood sample for pharmacokinetic analysis one day after applying a patch in patients with a stable fentanyl dose. ![]() These are factors that typically change during treatment and disease trajectories. body mass index) influence fentanyl exposure in patients with cancer. The aim of this study was to investigate whether smoking and body size (i.e. The transdermal fentanyl patch is widely used to treat cancer-related pain despite its wide inter- and intrapatient variability in pharmacokinetics. ![]()
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